Which of the following pairs correctly matches the RBC type with its disease association?

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Multiple Choice

Which of the following pairs correctly matches the RBC type with its disease association?

RBC morphology often points to specific disease processes. Drepanocytes, or sickle cells, are crescent-shaped red blood cells produced when hemoglobin S polymerizes in low-oxygen conditions. This characteristic shape is a hallmark of sickle cell disease, making this pair the correct match. Schistocytes are fragments of RBCs seen in microangiopathic hemolytic processes (like DIC, TTP, HUS), not specifically Thalassemia. Target cells appear in conditions with altered cell membrane-to-volume dynamics, notably thalassemia and liver disease, and are not the classic finding in aplastic anemia. Elliptocytes (ovalocytes) occur in hereditary elliptocytosis and some other states; megaloblastic anemia is more typically associated with macro-ovalocytes due to impaired DNA synthesis.

RBC morphology often points to specific disease processes. Drepanocytes, or sickle cells, are crescent-shaped red blood cells produced when hemoglobin S polymerizes in low-oxygen conditions. This characteristic shape is a hallmark of sickle cell disease, making this pair the correct match.

Schistocytes are fragments of RBCs seen in microangiopathic hemolytic processes (like DIC, TTP, HUS), not specifically Thalassemia. Target cells appear in conditions with altered cell membrane-to-volume dynamics, notably thalassemia and liver disease, and are not the classic finding in aplastic anemia. Elliptocytes (ovalocytes) occur in hereditary elliptocytosis and some other states; megaloblastic anemia is more typically associated with macro-ovalocytes due to impaired DNA synthesis.

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