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Multiple Choice

Which is the last stage capable of mitosis in the erythroid lineage?

In erythroid development, cells proliferate by mitosis during the early stages, while hemoglobin production and maturation proceed. The last stage that can still divide is the rubricyte, a late normoblast where the nucleus is still present and the cell can undergo mitosis. After this stage, the nucleus condenses and the cell enucleates during the next stage, forming a reticulocyte. Once enucleation has occurred, the cell no longer divides. So rubricyte is the final stage capable of mitosis in the erythroid lineage.

In erythroid development, cells proliferate by mitosis during the early stages, while hemoglobin production and maturation proceed. The last stage that can still divide is the rubricyte, a late normoblast where the nucleus is still present and the cell can undergo mitosis. After this stage, the nucleus condenses and the cell enucleates during the next stage, forming a reticulocyte. Once enucleation has occurred, the cell no longer divides. So rubricyte is the final stage capable of mitosis in the erythroid lineage.