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Multiple Choice

Where are integral proteins located in the RBC membrane?

Integral membrane proteins are embedded in the lipid bilayer and typically cross the membrane, spanning from the outside to the inside. In red blood cells, many essential proteins traverse the bilayer, allowing transport and signaling across the membrane, and their cytoplasmic portions can connect to the underlying cytoskeleton to help maintain cell shape. Peripheral proteins, by contrast, stay on one surface or attach to the cytoskeleton without crossing the membrane. Since integral proteins extend across the entire membrane, spanning its thickness, that description fits best.

Integral membrane proteins are embedded in the lipid bilayer and typically cross the membrane, spanning from the outside to the inside. In red blood cells, many essential proteins traverse the bilayer, allowing transport and signaling across the membrane, and their cytoplasmic portions can connect to the underlying cytoskeleton to help maintain cell shape. Peripheral proteins, by contrast, stay on one surface or attach to the cytoskeleton without crossing the membrane. Since integral proteins extend across the entire membrane, spanning its thickness, that description fits best.