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Multiple Choice

What is the last stage before reticulocyte in the erythropoietin- erythroblast series?

The last stage before a reticulocyte forms is the orthochromatic erythroblast. In this stage most hemoglobin is already present and the cytoplasm stains more eosinophilic as Hb content dominates. The nucleus becomes highly condensed (pyknotic) and is eventually expelled from the cell (enucleation) to produce the reticulocyte, which then enters the bloodstream and matures into a red blood cell. Earlier stages progressively build Hb and reduce ribosomal content, leading up to this final erythroblast stage before enucleation.

The last stage before a reticulocyte forms is the orthochromatic erythroblast. In this stage most hemoglobin is already present and the cytoplasm stains more eosinophilic as Hb content dominates. The nucleus becomes highly condensed (pyknotic) and is eventually expelled from the cell (enucleation) to produce the reticulocyte, which then enters the bloodstream and matures into a red blood cell. Earlier stages progressively build Hb and reduce ribosomal content, leading up to this final erythroblast stage before enucleation.