What is the first stage of hemoglobinization in erythropoiesis?

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What is the first stage of hemoglobinization in erythropoiesis?

Hemoglobinization begins when developing red cells start producing hemoglobin, which becomes visually evident at the polychromatophilic erythroblast stage, also known as the rubricyte. At this point the cytoplasm shifts from a deep blue (due to RNA and organelles) to a mixed blue-pink color as hemoglobin accumulates. Earlier precursors, like the proerythroblast and basophilic erythroblast, are largely focused on RNA and protein synthesis with little or no Hb, so their cytoplasm remains predominantly basophilic. As Hb build-up continues, the cell progresses to later stages, eventually forming cells with high Hb content ready to enucleate as reticulocytes.

Hemoglobinization begins when developing red cells start producing hemoglobin, which becomes visually evident at the polychromatophilic erythroblast stage, also known as the rubricyte. At this point the cytoplasm shifts from a deep blue (due to RNA and organelles) to a mixed blue-pink color as hemoglobin accumulates. Earlier precursors, like the proerythroblast and basophilic erythroblast, are largely focused on RNA and protein synthesis with little or no Hb, so their cytoplasm remains predominantly basophilic. As Hb build-up continues, the cell progresses to later stages, eventually forming cells with high Hb content ready to enucleate as reticulocytes.

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