What are the two common antiglycolytic agents used in blood collection?

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Multiple Choice

What are the two common antiglycolytic agents used in blood collection?

Explanation:
Preserving glucose in a blood sample requires stopping glycolysis carried out by blood cells after collection. Sodium fluoride blocks glycolysis by inhibiting enolase, preventing the final steps of the pathway. Lithium iodoacetate provides an additional blockade earlier in glycolysis by inhibiting glyceraldehyde-3-phosphate dehydrogenase. Using both together gives more robust glucose preservation than fluoride alone. The other options introduce anticoagulants like heparin or oxalate, which prevent clotting but don’t inhibit glycolysis, or mention fluoride alone. Therefore, the two common antiglycolytic agents used are sodium fluoride and lithium iodoacetate.

Preserving glucose in a blood sample requires stopping glycolysis carried out by blood cells after collection. Sodium fluoride blocks glycolysis by inhibiting enolase, preventing the final steps of the pathway. Lithium iodoacetate provides an additional blockade earlier in glycolysis by inhibiting glyceraldehyde-3-phosphate dehydrogenase. Using both together gives more robust glucose preservation than fluoride alone. The other options introduce anticoagulants like heparin or oxalate, which prevent clotting but don’t inhibit glycolysis, or mention fluoride alone. Therefore, the two common antiglycolytic agents used are sodium fluoride and lithium iodoacetate.

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