Sites of hematopoiesis in the hepatic phase.

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During the fetal hepatic phase the liver is the main site where blood cells form, but other lymphoid organs also participate in hematopoiesis. The spleen contributes as a secondary site, and the thymus and lymph nodes are involved in producing lymphoid cells during this period. This phase sits between the yolk sac phase and the eventual bone marrow–dominant phase, which becomes the primary site later in gestation and after birth. The heart, kidneys, brain, and spinal cord do not serve as hematopoietic sites in this developmental window.