In the NORMO- sequence of erythropoiesis, which term correctly begins the progression?

Study for the Hematology 1 Test. Utilize flashcards and multiple-choice questions with detailed explanations. Prepare effectively for success!

Multiple Choice

In the NORMO- sequence of erythropoiesis, which term correctly begins the progression?

The progression starts with the pronormoblast, the earliest erythroid precursor in the bone marrow. This cell, also called the proerythroblast, is large with a prominent nucleus and a basophilic (deep blue) cytoplasm due to abundant RNA. It marks the beginning of erythroid maturation, where hemoglobin synthesis begins and the cell prepares to condense its nucleus and shift cytoplasmic color as maturation proceeds. After this initial stage, the next steps are basophilic normoblast, then polychromatic normoblast, and finally orthochromatic normoblast, with further maturation leading to reticulocytes. The later stages reflect increasing hemoglobin content and progressive nuclear condensation and eventual extrusion. Therefore, pronormoblast is the starting term of the NORMO- sequence.

The progression starts with the pronormoblast, the earliest erythroid precursor in the bone marrow. This cell, also called the proerythroblast, is large with a prominent nucleus and a basophilic (deep blue) cytoplasm due to abundant RNA. It marks the beginning of erythroid maturation, where hemoglobin synthesis begins and the cell prepares to condense its nucleus and shift cytoplasmic color as maturation proceeds.

After this initial stage, the next steps are basophilic normoblast, then polychromatic normoblast, and finally orthochromatic normoblast, with further maturation leading to reticulocytes. The later stages reflect increasing hemoglobin content and progressive nuclear condensation and eventual extrusion. Therefore, pronormoblast is the starting term of the NORMO- sequence.

More practice questions