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Multiple Choice

In the erythroblast lineage, which stage directly precedes the Basophilic erythroblast?

Erythroid precursors mature in a defined sequence during erythropoiesis. The earliest recognizable erythroid precursor is the proerythroblast, a large cell with a prominent nucleus and very basophilic cytoplasm due to abundant RNA. This cell differentiates into the basophilic erythroblast, marking the next stage in the lineage as hemoglobin synthesis begins and the cell becomes progressively smaller with coarser chromatin. Therefore, the stage that directly precedes the basophilic erythroblast is the proerythroblast (also called pronormoblast; rubriblast is a synonym used in some texts). The other stages listed occur after basophilic erythroblast: the polychromatic erythroblast follows as hemoglobin synthesis increases and cytoplasm shifts color, and the orthochromatic erythroblast comes later as maturation progresses toward enucleation.

Erythroid precursors mature in a defined sequence during erythropoiesis. The earliest recognizable erythroid precursor is the proerythroblast, a large cell with a prominent nucleus and very basophilic cytoplasm due to abundant RNA. This cell differentiates into the basophilic erythroblast, marking the next stage in the lineage as hemoglobin synthesis begins and the cell becomes progressively smaller with coarser chromatin. Therefore, the stage that directly precedes the basophilic erythroblast is the proerythroblast (also called pronormoblast; rubriblast is a synonym used in some texts). The other stages listed occur after basophilic erythroblast: the polychromatic erythroblast follows as hemoglobin synthesis increases and cytoplasm shifts color, and the orthochromatic erythroblast comes later as maturation progresses toward enucleation.