In the context of sickle cell disease, what term describes the abnormal red blood cell shape?

Study for the Hematology 1 Test. Utilize flashcards and multiple-choice questions with detailed explanations. Prepare effectively for success!

Multiple Choice

In the context of sickle cell disease, what term describes the abnormal red blood cell shape?

The key idea is the term used for the sickle-shaped red blood cell. In sickle cell disease, red cells deform into a crescent or sickle shape when hemoglobin S polymerizes in low-oxygen conditions. That distinctive shape is called a drepanocyte. The name comes from the Greek word for sickle, reflecting this characteristic morphology. Other RBC shapes—elliptocytes (oval-shaped), schistocytes (fragmented cells), and target cells (bull’s-eye appearance)—describe different conditions or contexts and do not represent the classic sickling seen in this disease.

The key idea is the term used for the sickle-shaped red blood cell. In sickle cell disease, red cells deform into a crescent or sickle shape when hemoglobin S polymerizes in low-oxygen conditions. That distinctive shape is called a drepanocyte. The name comes from the Greek word for sickle, reflecting this characteristic morphology. Other RBC shapes—elliptocytes (oval-shaped), schistocytes (fragmented cells), and target cells (bull’s-eye appearance)—describe different conditions or contexts and do not represent the classic sickling seen in this disease.

More practice questions