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Multiple Choice

From one rubriblast, how many erythrocytes are produced?

In erythroid development, the rubriblast is the first true erythroid precursor that undergoes several rounds of mitosis to expand the cell number before enucleation. Each cell division doubles the number of cells, and there are four rounds of division before maturation to erythrocytes: 1 → 2 → 4 → 8 → 16. These divisions occur while the cells progressively synthesize hemoglobin and then shed their nuclei to become reticulocytes, which finally mature into erythrocytes. Therefore, from a single rubriblast, 16 erythrocytes are produced.

In erythroid development, the rubriblast is the first true erythroid precursor that undergoes several rounds of mitosis to expand the cell number before enucleation. Each cell division doubles the number of cells, and there are four rounds of division before maturation to erythrocytes: 1 → 2 → 4 → 8 → 16. These divisions occur while the cells progressively synthesize hemoglobin and then shed their nuclei to become reticulocytes, which finally mature into erythrocytes. Therefore, from a single rubriblast, 16 erythrocytes are produced.